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The body cannot make it
Ultimately, it leads to increased vascular permeability, defective angiogenesis, and activation of pro-inflammatory pathways, which finally hinders wound healing (Figure 6)
The mechanism likely involves the same angiogenic pathway: bone repair is acutely dependent on vascularization of the fracture gap, and BPC-157's VEGF-stimulating activity addresses this bottleneck directly
The titration schedule plays a critical rolegradual dose escalation, as recommended in FDA labeling, allows for physiological adaptation and typically results in fewer and shorter-duration side effects compared to rapid dose increases